This is perhaps one of Shakespeare's more interesting plays, if you will. In comparison to Macbeth it isn't quite the walk in the park.
I think conceptually it enables the reader to see that characters can influence characters to such a degree that the original traits are masked and changed. Tragedy in this play is definitely a main component - and a great emphasis that perhaps the villain doesn't always find their true defeat. In a way, wasn't the "villain" successful? He lied to everyone and pretty much killed whomever got in his way.
Othello is referred to as a "Barbary horse" () and a "lascivious Moor" (). In he denounces Desdemona's supposed sin as being "black as mine own face." Desdemona's physical whiteness is otherwise presented in opposition to Othello's dark skin: "that whiter skin of hers than snow." Iago tells Brabantio that "an old black ram / is tupping your white ewe" (). In Elizabethan discourse, the word "black" could suggest various concepts that extended beyond the physical colour of skin, including a wide range of negative connotations.  
Othello's destructiveness—and his determination to punish Desdemona for cheating on him—stem from his rage that Desdemona's immoral actions have also damaged him. What makes Othello so furious, Garber suggests, is that, when it comes to himself, Othello is a perfectionist. This all reflects pretty poorly on Othello.
But let's take a step back. Why is Othello a self-obsessed perfectionist in the first place? Othello's dangerous perfectionism may stem from his position as being consistently viewed as an outsider, simply because he's a black man in white Venetian society. Othello only could have risen to his position of power through incredible self-discipline.